human peripheral blood mononuclear cell
[대역어] None
[용어속성] Term
[용어속성] Term
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응
Research Article
[키워드] absence
accompanied
adaptive immune responses
Anti-viral
anti-viral IFN
anti-viral response
antiviral responses
Asymptomatic
asymptomatic SARS-CoV-2 infected subjects
Cell
cells
cellular
characterized
chemokine
chemokines
circulating
contribute
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 pathogenesis
COVID-19 patient
Critically ill
Critically ill patient
critically ill patients
cytokine
Cytokine storm
Cytokines
death
Defense
dendritic cell
dendritic cells
disease severity
early phase
elevated
ENhance
epithelial cells
event
Evidence
Ex vivo
expression
fine-tune
Frequency
hospitalized patient
hospitalized patients
Host
host defense
Host-directed therapies
host-directed therapy
human peripheral blood mononuclear cell
IFN
IFN-stimulated gene
Immune cell
immune cells
immune responses
Immunity
IMPROVE
in vitro
induce
Infection
Inflammatory cytokine
Inflammatory cytokines
inflammatory phenotype
inhibiting viral replication
Innate
innate immune response
Innate immunity
Interaction
interferon
interferons
investigated
low frequency
Lung epithelial cells
mechanism
mononuclear cell
multi-organ failure
neuropilin
observation
Pathogenesis
PBMC
PD-L1 marker
pDC/type I IFN axis
Peripheral blood
pharmacological strategy
phenotype
plasmacytoid dendritic cell
plasmacytoid dendritic cells
pro-inflammatory cytokine
pro-inflammatory cytokines
producing
productive viral replication
progression
protective role
regulate
Regulation
released
responsible
resulting
SARS-CoV-2
SARS-CoV-2 infected subject
SARS-COV-2 infection
SARS-CoV-2 pandemic
secreted
secretion
serum
severe COVID-19
Severe COVID-19 Infection
severe COVID-19 patients
stratified
the cytokine storm
the interferon
tissue damage
TLR7/8
type I
type I and III IFNs
type I and III interferons
Type I IFN
type I IFN producing cells
Viral
viral replication
Viral resistance
virus
viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents
Short communication
[키워드] acute lung injury
acute respiratory distress syndrome
addition
anti-cytokine storm
ARDSacute respiratory distress syndrome
BALFbronchoalveolar lavage fluid
Bronchoalveolar lavage fluid
candidate
caused
CCL-5chemokine (C-C motif) ligand 5
chemokine (C-C motif) ligand 5
Coronavirus disease 2019
COVID-19
COVID-19coronavirus disease 2019
CSS
CSScytokine storm syndrome
CXC chemokine ligand 1
CXCL1CXC chemokine ligand 1
Cytokine storm syndrome
drug
drug library
Drug repurposing
effective
entecavir
FDAU.S. Food and Drug Administration
G-CSFgranulocyte-colony stimulating factor
granulocyte-colony stimulating factor
half-maximal inhibitory concentration
high mortality
hPBMChuman peripheral blood mononuclear cell
human peripheral blood mononuclear cell
IC50half-maximal inhibitory concentration
IL-10
ILInterleukin
Inflammatory cytokine
inhibited
interferon-γ-inducible protein 10
interleukin
Intervention
IP10interferon-γ-inducible protein 10
lipopolysaccharide
LPSlipopolysaccharide
Macrophage
macrophage inflammatory protein 1 alpha
MCP-1monocyte chemoattractant protein -1
MERSMiddle East Respiratory Syndrome
mice
Middle East respiratory syndrome
MIP-1αmacrophage inflammatory protein 1 alpha
mitigate
monocyte chemoattractant protein -1
mononuclear cell
NF-κB
NLR family PYRIN domain containing-3
NLRP3NLR family PYRIN domain containing-3
patients
Peripheral blood
reduce
respiratory
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2Severe Acute Respiratory Syndrome Coronavirus -2
Severe Acute Respiratory Syndrome Coronavirus -2
Spread
suppressed
survival
syndrome
TNF-α
Treatment
U.S. Food and Drug Administration
[DOI] 10.1016/j.biopha.2020.110643 [Article Type] Short communication
[DOI] 10.1016/j.biopha.2020.110643 [Article Type] Short communication